Sustris was born in Amsterdam and may have been a pupil of Jan van Scorel or of
Heemskerck in Utrecht. He worked in
oil and
fresco and was noted for his portraits and landscapes. He arrived in Venice between 1534 and 1538, and worked as an associate of
Titian both in Venice and at the Imperial court at Augsburg in 1548 and 1550-2. He later worked in Padua and Venice.