La Hyre was the son of the painter Etienne de La Hyre. He was born in Paris. He was influenced first by Primaticcio's work at
Fontainebleau, then by
Caravaggism before adopting in his later years the lighter palette and more serene style which marks much of French painting around 1640-60.
He became a member of the
Academy in 1648. He undertook decorative schemes for Paris town-houses,
tapestry designs and altarpieces for Parisian churches. He also painted a number of landscapes.