Gregorio di Cecco di Luca was a painter living in Siena, Italy in the 15th century.
In 1402, he was registered with the Sienese painters’ guild. In 1418, he was paid for painting a cover for Sienese public records (known as a Biccherna panel).
Gregorio di Cecco di Luca was greatly influenced by Taddeo di Bartolo. In 1420, he signed an altarpiece with Taddeo in the Marescotti chapel of the church of Sant’Agostino in Siena. He became Taddeo’s adoptive son and heir in 1422.
In 1421, Gregorio was part of the commission overseeing the construction of the church and loggia of San Paolo in Siena. His only surviving signed work is the ‘Madonna of Humility’ (Museo dell’Opera del Duomo, Siena) dated 1423.